Basic Molecular Information

Basic Information

DICL ID
DICL_CP_0318596
PubChem CID
Molecular Formula
C10H5Cl2NO3
Molecular Weight
258.06 g/mol
Synonyms/Alias
[5;7-Dichlorokynurenic acid; 131123-76-7; 5;7-DICHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID; 5;7-Dcka; 5;7-Dichloroquinurenic acid; 2-Quinolinecarboxylic acid; 5;7-dichloro-4-hydroxy-; 5;7-Dichorokynu...
InChI Key
BGKFPRIGXAVYNX-UHFFFAOYSA-N
InChI
InChI=1S/C10H5Cl2NO3/c11-4-1-5(12)9-6(2-4)13-7(10(15)16)3-8(9)14/h1-3H,(H,13,14)(H,15,16)
IUPAC Name
5,7-dichloro-4-oxo-1H-quinoline-2-carboxylic acid
CAS Number
131123-76-7

Structure Information

Chemical Structure Visualization

SMILES Notation
2D Molecular Drawing
Carbon (C)
Hydrogen (H)
Oxygen (O)
Nitrogen (N)
Sulfur (S)
SDF

21 22 0 0 0 0 0 0 0 0999 V2000
-1.4278 1.3454 -0.6803 C 0 0 0 0 0 0 0 0 0 0 0 0
-2.7808 1.0134 -0.6533 C 0 0 0 0 0 0 0 0 0 0 0 0
-3.1857 -0.226...

Experimental Data

Activity Data

Target Ion Channel
Ionotropic glutamate receptor subunit GluN1(F484A/T518L)/N3A
Uniprot Accession Number
Function
Antagonist
Species
Homo sapiens (Human)
IC50
IC50: 41000 nM
EC50
N/A (Not available)
Ki
N/A (Not available)
Kd
N/A (Not available)
Inhibition
N/A (Not available)

Experimental Conditions

pH
pH 7.4
Holding Potential
−40 mV mV
Temperature
Room Temperature
Test Method
Patch-clamping
Test Species
Xenopus laevis oocyte

Binding Information

Binding Site
Extracellular domain
Binding Site Residue
glycine binding site

Disease Information

Related Disease
Not specified

References

URL
N/A (Not available)
PMID
Patent
N/A (Not available)

Computed Properties

Heavy Atom Count
16
Rotatable Bonds
1
logP
2.5331
Complexity
61.548
TPSA (Ų)
70.16
H-Bond Donors
2
H-Bond Acceptors
2
Ring Count
2
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